The Department of Pediatrics I (Director: Prof. Dr. med. Johannes Schulte) aims to sustainably improve the prognosis of serious malignant diseases in children and adolescents. In the areas of hematology and oncology in particular, the aim is to implement innovative therapies such as patient-specific anti-tumor peptide bacteria into standard therapy. The currently ongoing PERVISION study, carried out on patients with metastatic, fusion-driven sarcomas (DKTK-funded, clinical director Prof. Dr. Martin Ebinger, co-director of the GPOH soft tissue sarcoma study group), is investigating whether the chances of a permanent cure in these patients can be improved after therapy and achieving remission with peptide vaccination with fusion peptide.

 

The working group of Prof. Dr. Karin Schilbach is working on molecularly characterizing T cell responses against sarcoma-specific epitopes, especially against the fusion peptide, in order to potentially enable the production of sarcoma-specific T cells via T cell receptor heterodimer identification. This work is to be continued.

Your tasks:

• Establishment of your own research group, including the acquisition of external funding for independent research projects wie PhD and Master students
  
• Commitment to research and teaching, the endeavour to obtain a habilitation will be supported
• Development of an NGS-based immune monitoring system for innovative immunotherapies in our clinic (e.g. the immune monitoring of the PerVision clinical trial, patient-individual tumor-specific peptide vaccines, detection of anti-tumor T-cell responses after vaccination or immunotherapy-induced stromal revision)
• Establishment of a library of epitope-specific TCRs with defined HLA restriction for uniform tumor epitopes
• Functional validation of identified TCRs in in vitro models and translation into clinical applications
• Perdorming multi-omic analyses (transcription, phenotype) at bulk and single cell level
  

Your profile:

• Master's and PhD degree in medical science, cell or molecular biology, immunology
• Stong background in research areas such as tumour biology an immunolgy, T-cell-immunology, molocular biology or systems biology
• Hands-on experience with standard and advanced molelcular and cell biology techniques, as well as bioinformatics and statistical analysis
• Excellent written and spoken English
• Independent analytical thinking, flexibility, sense of responsibility, diligence and team spirit

We offer you:

• Collaboration in the diverse environment of a modern university hospital, which, in addition to patient care, also focuses on medical research and teaching
• Interdisciplinary work with colleagues from other departments and universities in joint projects/multi-center studies 
• Future-proof job and location as well as attractive remuneration including company pension scheme (VBL) with the most flexible working hours possible
• Subsidy for tickets for local public transport and attractive discounts on our offer platforms for employees
• Structured onboarding phase, hospital's own academy to expand technical, social and methodological skills
• Health care through a wide range of sports activities

We offer remuneration in accordance with TV-L (collective wage agreement for the Public Service of the German Federal States), severely handicapped persons with equal qualifications are given preferential consideration. Interview expenses are not covered. Please note the applicable vaccination regulations.